Antrodia cinnamomea profoundly exalted the reversion of activated hepatic stellate cells by the alteration of cellular proteins.
作者： Yi-Ren Chen , Kai-Ting Chang , May-Jywan Tsai , Chia-Hung Lee , Kao-Jean Huang
DOI: 10.1016/J.FCT.2014.04.006
关键词:
摘要: The direct modulation of Antrodia cinnamomea (AC) on the prominent role liver fibrosis-hepatic stellate cells (HSCs) in situ remains unclear. Firstly, administration A. mycelial extract (ACME) could improve morphology and histological changes including collagen formation GPT activity thioacetamide (TAA)-injured rats. fatty acid restore TAA-induced HSCs (THSCs) returned to non-chemical induced (NHSCs) type as measured by immunofluorescence Oil Red O staining. PPARγ was upregulated associated with lowering α-SMA protein NHSC-ACME. ACME inhibited MMP-2 NHSCs gelatin Zymography. After LC–MS/MS, cytoskeleton (tubulin, lamin A) heat shock 8 NHSC-ACME, guanylate kinase, brain-specific SG-II p55 proteins were downregulated THSC-ACME. Whereas MHC class II, SMC6 protein, phospholipase D Furthermore, PKG-1 NHSC-ACME THSC-ACME Western blotting. Taken together, beneficial effect induction HSC cellular is potentially applied an alternative complementary medicine for prevention amelioration a injury.
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