Serum concentrations of collagen degrading enzymes and their inhibitors after downhill running

摘要: In the present study release of proteins degrading extracellular matrix compounds to circulation was measured after damaging exercise in humans. Muscle damage induced by downhill running; furthermore, performed at both cold temperature (5 degrees C) and room (22 also possible effect environmental on serum concentrations metalloproteinases MMP-2 MMP-9, tissue inhibitors TIMP-1 TIMP-2, MMP-2/TIMP-2 complex, muscle monitored creatine kinase measurements. Results were compared with those obtained from patients having rhabdomyolysis, myositis Becker muscular dystrophy. The demonstrates an acute increase TIMP-1, but no changes response eccentric exercise. Serum activity data suggest greater running a environment than temperature. observations about most slight MMP TIMP lack their correlation increased indicate that measurements MMPs TIMPs do not sensitively respond skeletal regeneration. On other hand, severe damage, such as dystrophy, seemed have concentrations.