Threshold altitude for bubble decay and stabilization in rat adipose tissue at hypobaric exposures.

摘要: Introduction Bubble formation during altitude exposures, causing decompression sickness (aDCS), has been referred to in theoretical models as venous gas embolisms (VGE). This also demonstrated by intravascular formation. Previous reports indicate that the of VGE and aDCS incidence increase abruptly for exposures exceeding 40-44 kPa ambient pressures. Further, extravascular micro air bubbles injected into adipose tissue grow transiently, then shrink disappear while breathing oxygen (F1O2 = 1.0) at 71 kPa. At 25 similar will stabilize without disappearing. We hypothesize an pressure threshold either bubble stabilization or disappearance may be identified between Whether above a certain not before. Methods In anesthetized rats, (containing 79% nitrogen) 500 nl were exposed abdominal tissue. Rats decompressed 2-35 min 60, 47, 36 studied 215 continued 1). Results Significantly more shrank disappeared 60 (14 17) 47 15) compared (3 pressure. Conclusion The results decay is are agreement with previous demonstrating symptoms altitudes higher than 44