Drugs, their targets and the nature and number of drug targets

作者: Peter Imming , Christian Sinning , Achim Meyer

DOI: 10.1038/NRD2132

关键词:

摘要: … The latter list illustrates well the point discussed previously: that in many cases it will not help to know a single target, because the clinical effect is caused by patterns of …

参考文章(276)
Thomas R. Kleyman, Thomas Kieber-Emmons, Farhad Kosari, Shaohu Sheng, Mechanism of action of amiloride: a molecular prospective. Seminars in Nephrology. ,vol. 19, pp. 524- 532 ,(1999)
Nicosia S, Pharmacodynamic properties of leukotriene receptor antagonists. Monaldi archives for chest disease = Archivio Monaldi per le malattie del torace / Fondazione clinica del lavoro, IRCCS [and] Istituto di clinica tisiologica e malattie apparato respiratorio, Università di Napoli, Secondo ateneo. ,vol. 54, pp. 242- ,(1999)
John W. Yarbro, Mechanism of action of hydroxyurea. Seminars in Oncology. ,vol. 19, pp. 1- 10 ,(1992) , 10.5555/URI:PII:009377549290123I
P Honerjäger, H Nawrath, Pharmacology of bipyridine phosphodiesterase III inhibitors. European Journal of Anaesthesiology - Supplement. ,vol. 5, pp. 7- 14 ,(1992)
David P. Calfee, Frederick G. Hayden, New approaches to influenza chemotherapy. Neuraminidase inhibitors. Drugs. ,vol. 56, pp. 537- 553 ,(1998) , 10.2165/00003495-199856040-00003
Sonneville A, [Hypostamine (tritoqualine), a synthetic reference antihistaminic]. Allergie et immunologie. ,vol. 20, pp. 365- ,(1988)
J. Hofmann, Modulation of protein kinase C in antitumor treatment Reviews of Physiology Biochemistry and Pharmacology. ,vol. 142, pp. 1- 96 ,(2001) , 10.1007/BFB0117491
T Rogosch, L A Dailey, M Ramadan, T Buss, A Meyer, H Morck, P Imming, A classification of drug substances according to their mechanism of action. Die Pharmazie. ,vol. 59, pp. 579- 589 ,(2004)
G B Baker, R L Sherry-McKenna, R T Coutts, K F McKenna, Insights into the mechanisms of action of the MAO inhibitors phenelzine and tranylcypromine: a review. Journal of Psychiatry & Neuroscience. ,vol. 17, pp. 206- 214 ,(1992)
F. Estelle R. Simons, Advances in H1-Antihistamines The New England Journal of Medicine. ,vol. 351, pp. 2203- 2217 ,(2004) , 10.1056/NEJMRA033121