Cortical amino acids in Brains with pathological features of Parkinson’s and Alzheimer’s diseases
作者： Ross A. Clevens , M. Flint Beal , David W. Ellison
DOI: 10.1007/BF03160135
关键词:
摘要: The postmortem levels of the amino acid neurotransmitters GABA, glutamate, aspartate, and taurine were measured in 7 cerebral cortical regions from a group demented patients with neuropathological features both Parkinson’s disease (PD) alzheimer’s (AD) neurologically normal controls. Concentrations gamma-aminobutyric (GABA) significantly (p<0.02) reduced by 27–43% superior temporal, parahippocampal, cingulate, post-central gyri. There no significant changes taurine. GABA deficits are similar to those found AD lend support proposal that dementia PD is frequently related coincidence AD.
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