Kinetics and mechanism of degradation of lithospermic acid B in aqueous solution
作者： Yong-Xue Guo , Zhi-Long Xiu , Dai-Jia Zhang , Hui Wang , Long-Xing Wang
DOI: 10.1016/J.JPBA.2006.10.025
关键词:
摘要: The degradation of lithospermic acid B (LAB) was investigated as a function buffer concentration, pH and temperature. Stability tests were performed using stability-indicating high-performance liquid chromatography (HPLC) with UV-vis detection. followed pseudo-first-order kinetics under all experimental conditions. maximum stability LAB observed at 2.0. logk(pH)-pH profile described by specific acid-base catalysis water molecules agreed the results. overall rate constant temperature given conditions obeyed Arrhenius equation. chemical fate in mild acidic solution investigated, nine products detected tentatively identified LC-MS analysis. primary pathway involving cleavage ester bond ring-opened benzofuran are proposed.
elsevier.com
sci-hub.se 参考文章(13)
Jin-lan Zhang, Ming Cui, Yun He, Hai-lan Yu, De-an Guo, Chemical fingerprint and metabolic fingerprint analysis of Danshen injection by HPLC-UV and HPLC-MS methods. Journal of Pharmaceutical and Biomedical Analysis. ,vol. 36, pp. 1029- 1035 ,(2005) , 10.1016/J.JPBA.2004.09.009
Yong-Xue Guo, Dai-Jia Zhang, Hui Wang, Zhi-Long Xiu, Long-Xing Wang, Hong-Bin Xiao, Hydrolytic kinetics of lithospermic acid B extracted from roots of Salvia miltiorrhiza. Journal of Pharmaceutical and Biomedical Analysis. ,vol. 43, pp. 435- 439 ,(2007) , 10.1016/J.JPBA.2006.07.046
Dae Gill Kang, Hyuncheol Oh, Eun Jin Sohn, Tae Young Hur, Kang Chang Lee, Kwang Jin Kim, Tai Yo Kim, Ho Sub Lee, Lithospermic acid B isolated from Salvia miltiorrhiza ameliorates ischemia/reperfusion-induced renal injury in rats. Life Sciences. ,vol. 75, pp. 1801- 1816 ,(2004) , 10.1016/J.LFS.2004.02.034
Takako Yokozawa, Hae Young Chung, Erbo Dong, Hikokichi Oura, Confirmation that magnesium lithospermate B has a hydroxyl radical-scavenging action Experimental and Toxicologic Pathology. ,vol. 47, pp. 341- 344 ,(1995) , 10.1016/S0940-2993(11)80344-1
S.Craig Dyar, Robert E. Notari, Hydrolysis kinetics and stability predictions for a mixture of R and S temocillin isomers International Journal of Pharmaceutics. ,vol. 173, pp. 221- 232 ,(1998) , 10.1016/S0378-5173(98)00239-7
Takako Yokozawa, Tae Woong Lee, Hikokichi Oura, Gen-ichiro Nonaka, Itsuo Nishioka, Effect of magnesium lithospermate B in rats with sodium-induced hypertension and renal failure. Nephron. ,vol. 60, pp. 460- 465 ,(1992) , 10.1159/000186809
Koji Hase, Rena Kasimu, Purusotam Basnet, Shigetoshi Kadota, Tsuneo Namba, Preventive effect of lithospermate B from Salvia miltiorhiza on experimental hepatitis induced by carbon tetrachloride or D-galactosamine/lipopolysaccharide Planta Medica. ,vol. 63, pp. 22- 26 ,(1997) , 10.1055/S-2006-957596
Takeshi Shigematsu, Shingo Tajima, Takeji Nishikawa, Saood Murad, Sheldon R. Pinnell, Itsuo Nishioka, Inhibition of collagen hydroxylation by lithospermic acid magnesium salt, a novel compound isolated from Salviae miltiorrhizae Radix Biochimica et Biophysica Acta (BBA) - General Subjects. ,vol. 1200, pp. 79- 83 ,(1994) , 10.1016/0304-4165(94)90030-2
Chun-bo Ai, Lian-niang Li, Salvianolic Acids D and E: Two New Depsides from Salvia miltiorrhiza. Planta Medica. ,vol. 58, pp. 197- 199 ,(1992) , 10.1055/S-2006-961428
Mingxing Zhou, Robert E. Notari, Influence of pH, temperature, and buffers on the kinetics of ceftazidime degradation in aqueous solutions. Journal of Pharmaceutical Sciences. ,vol. 84, pp. 534- 538 ,(1995) , 10.1002/JPS.2600840504