The prevalence of leucocyte alloantibodies in blood donors from South China
作者： W. Xia , X. Ye , X. Xu , D. Chen , J. Deng
DOI: 10.1111/TME.12276
关键词:
摘要: SUMMARY Background Several studies had demonstrated that leucocyte antibodies including anti-human antigen (anti-HLA) (class I and class II) neutrophil (anti-HNA) (HNA-1, -2 -3) present in the blood products are responsible for transfusion-related acute lung injury (TRALI). Therefore, selection of exclusive anti-HLA anti-HNA may lower risk TRALI reaction. However, prevalence among donors China is currently not known. Study design methods Blood samples were collected from 454 male 560 female (143 nulliparous 417 multiparous female). HLA II analyzed by bead assays. Anti-HNA-1 screened LABScreen assay (One Lambda Inc.), HNA-3 detected capture assay, confirmed granulocyte agglutination test (GAT). Results Screening total cohort showed higher compared with (19·64 vs 4·63%). We found against (13·21%) (11·43%) donors. The most frequent parous females (n = 69) reacted A*11 (28·81%), B*07 (42·37%), Cw*07 (20·34%) DRB1*04 (40·43%) molecules. Among 778 (randomly selected 1014 donors), we three reactive antibodies, two HNA-2 one without known specificity. Anti-HNA-3 so far. Conclusion In this study, alloimmunization I, HNA 4·63, 24·70 0·39%, respectively, our donors, indicating use plasma containing pre-testing increase Although immunization seems to be a rare event China, further observation necessary decide necessity screening
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