Interactions of light and sodium nitrite in producing relaxation of rabbit aorta.

摘要: In rings of rabbit aorta mounted in muscle chambers, endothelial-independent reversible relaxation produced by irradiation with long wavelength was potentiated the presence 1 mM NaNO2. Photorelaxation NaNO2, but not its absence, further superoxide dismutase. The interaction light and NaNO2 producing relaxations studied a perfusion-superfusion system which Krebs' solution (37 degrees C, 95% O2-5% CO2) or without added perfused (2 ml/min) through glass tube (1.25 mm, inside diameter) on way to superfusing an endothelium-free aortic ring few seconds downstream. UV either flowing could be made separately. ring, for tension recording, precontracted similar level tone absence l-phenylephrine HCl. direct markedly significantly 10 U/ml dismutase, inhibited Hb (1-10 microM) MetHb (10 microM). Irradiation perfusing no downstream only small at When dismutase present along (15-120 sec) marked relaxation, magnitude increasing concentration (1 microM-1 mM). This (complete 0.3-1 partly microM).(ABSTRACT TRUNCATED AT 250 WORDS)