Diseases affected by vitamin D: sun exposure

摘要: Solar ultraviolet B (UVB) irradiance, through production of vitamin D, is important in human health. In response to solar UV doses, skin pigmentation adapted over millennia where people lived, changing from dark the African plains light Northern Europe. Many ecological (geographical) studies have inversely correlated about 20 types cancer with UVB doses. Observational along empirical data two randomized controlled trials (RCTs) largely support these findings. Research has generally revealed mechanisms whereby D can reduce risk. By inducing cathelicidin and defensins, reduces risk several bacterial viral infections. Bacterial infections strong evidence UVB/vitamin effects include dental caries, periodontal disease, pneumonia, sepsis, tuberculosis. Viral infectious diseases similar Epstein-Barr virus-linked such as Hodgkin’s lymphoma, multiple sclerosis, mononucleosis, well type A influenza. also other autoimmune diseases, including inflammatory bowel disease/Crohn’s rheumatoid arthritis, 1 diabetes mellitus. Good for beneficial roles reducing cardiovascular disease (CVD) comes observational prediagnostic serum 25-hydroxyvitamin seasonality CVD incidence or mortality rates. That cold temperature appears be an factor tends somewhat cloud studies. However, same effect applies influenza, yet RCTs found supplementation. Although are often called definitive proof that various criteria causality a biological system A.B. Hill established 1965 serve alternative approach.