The Bystander Effect in Radiation Oncogenesis: I. Transformation in C3H 10T½ Cells In Vitro can be Initiated in the Unirradiated Neighbors of Irradiated Cells

摘要: Abstract Sawant, S. G., Randers-Pehrson, Geard, C. R., Brenner, D. J. and Hall, E. The Bystander Effect in Radiation Oncogenesis: I. Transformation C3H 10T½ Cells In Vitro can be Initiated the Unirradiated Neighbors of Irradiated Cells. It has long been accepted that radiation-induced genetic effects require DNA hit damaged directly by radiation. Recently, evidence accumulated cell populations exposed to low doses α particles, biological occur a larger proportion cells than are estimated have traversed particles. end points observed include chromosome aberrations, mutations gene expression. development fast single-cell microbeam now makes it possible expose precisely known population exactly defined numbers assay for oncogenic transformation. delivered no, one, two, four or eight particles through nuclei all just 10% 10...