More than Just a Quorum: Integration of Stress and Other Environmental Cues in Acyl-Homoserine Lactone Signaling

摘要: Many bacteria employ chemical communication to coordinate group behaviors, a process that has been termed quorum sensing (QS). Although many different classes of use QS, the mechanism emerged as common in gram-negative proteobacteria is based on acyl-homoserine lactone (acyl-HSL) signal molecules. QS an important field study because its regulatory roles pathogenic and environmental bacteria. Acyl-homoserine (Acyl-HSL) controls virulence plant animal pathogens such Pseudomonas aeruginosa, Burkholderia cepacia, Agrobacterium tumefaciens. This chapter focuses integration acyl-HSL stress responses. In P. expression numerous factors extracellular enzymes (LasB elastase, LasA protease, alkaline protease), secondary metabolites (pyocyanin, hydrogen cyanide, pyoverdin), toxins (exotoxin A). Microarray studies revealed las rhl systems together control more than 300 genes. The majority associated genes are predicted encode secreted secretion machinery, confirming notion core function factors. Indeed, recent population analysis concurrently isolated aeruginosa from individual Cystic fibrosis (CF) lung infections great heterogeneity phenotypes genotypes within well among patients. finding suggests single selective mechanism, whether social or nonsocial nature, unlikely explain emergence variants during CF infection.