Assessment of Multidrug Resistance

作者: G. D. Luker , K. E. Luker , V. Sharma , V. V. Rao , D. Piwnica-Worms

DOI: 10.1007/978-3-642-58643-9_20

关键词:

摘要: Resistance of malignant tumors to chemotherapeutic agents is a major cause treatment failure in patients with cancer [1-3]. The phenotype known as multidrug resistance (MDR) characterized by the respond variety structurally and functionally diverse drugs same or unrelated chemical classes, despite initial only single agent. Classically, such refractory behavior multiple would occur recurring tumors; however, it appears that may also exhibit MDR at time presentation. Molecular mechanisms for have been analyzed studies tumor cell lines isolated selected cytotoxic drugs. Several different involving overlapping, but distinct, patterns drug identified, which include changes topoisomerases, superoxide dismutases, glutathione transferases, expression transport proteins pglycoprotein (MDR1 Pgp) resistance-associated protein (MRP) [4-7]. These forms independently combination. Of MDR, overexpression MDR1 Pgp this phenotype, one best mediators MDR. In chapter, we will focus on molecular biology, clinical impact, potential functional scintigraphic imaging attributed tumors.

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