Squamous cell carcinoma of the skin: epidemiology, classification, management, and novel trends

摘要: Squamous cell carcinoma (SCC) is the second most common non-melanoma skin cancer. It originates from epidermal keratinocytes or adnexal structures (such as eccrine glands pilosebaceous units). We describe salient features of cutaneous SCC. also review novel classification schemes proposed during last decade which attempt to stratify SCC lesions based on prognosis. Biopsy leads definitive diagnosis. Treatment includes surgical excision; Mohs micrographic surgery produces excellent cure rates and spares maximal amount tissue. Other modalities include electrodessication curettage, cryosurgery, radiotherapy, topical medications, photodynamic therapy, systemic therapy. Management follow-up depend risk stratification individual lesions.