A detailed multipoint map of human chromosome 4 provides evidence for linkage heterogeneity and position-specific recombination rates.

摘要: Utilizing the CEPH reference panel and genotypic data for 53 markers, we have constructed a 20-locus multipoint genetic map of human chromosome 4. New RFLPs are reported four loci. The integrates high-resolution 4p16 into continuous extending to 4q31 an unlinked cluster three loci at 4q35. 20 linked markers form linkage group 152 cM in males 202 females. Likely locations provided 25 polymorphic anonymous sequences 28 gene-specific RFLPs. was employing LINKAGE CRIMAP computational methodologies build via stepwise algorithm. A detailed 10-point region from provides evidence heterogeneity maps families segregating Huntington disease (HD). It additionally position-specific recombination frequencies telomeric 4p.