Artificial colloids impair haemostasis. An in vitro study using thromboelastometry coagulation analysis.

摘要: Background:  Hydroxyethyl starch (HES) solutions impair haemostatic mechanisms. The impact of the degree substitution (DS) a HES solution on thromboelastometry tracings is unclear. Therefore we tested hypothesis whether DS has an effect defect caused by HES, and assessed whole blood coagulation analysis (ROTEM®, Pentapharm Co., Munich, Germany) in serial vitro haemodilutions colloids. Methods:  Whole was withdrawn from 12 volunteers crossover study. Six per cent low-molecular weight with high (HES MW 120 kDa/degree 0.7) low 130 kDa/0.4) substitution, 4% succinylated gelatin (GEL) or albumin (ALB) added to citrated venous samples make 20, 40, 60 vol.% end-concentrations each solutions. Samples were analyzed ROTEM®. Results:  There comparable decrease maximum clot firmness (MCF) shear elastic modulus [G = 5000 × MCF/(100–MCF)] 120/0.7 130/0.4 at 20 40 dilutions. At dilution decreased less alpha-angle MCF than (P < 0.05). With moderate dilutions all colloids shortened time (CT). G more both groups ALB GEL Furthermore, deteriorated group (P < 0.05). Conclusion: In modest. Haemodilution induced fewer abnormalities HES. In addition, haemodilution impaired solution.