Understanding the role of P2X7 in affective disorders—are glial cells the major players?

摘要: Pathophysiology associated with several psychiatric disorders has been linked to inflammatory biomarkers. This generated a theory of major depressive as an disease. The idea pro-inflammatory cytokines altering behavior is now well accepted however many questions remain. Microglia can produce plethora and these cells appear be critical in the link between changes disorders. play known role sickness which components depressive-like such social withdrawal, sleep alterations, anorexia. Numerous candidate genes have identified for last decade. Single nucleotide polymorphisms (SNPs) human P2X7 gene bipolar disorder, depression, severity symptoms. ligand-gated cation channel expressed on microglia lower levels found astrocytes some neuronal populations. In regulator interleukin-1 family. Genetic deletion mice protective addition responses. P2X7−/− shown demonstrate anti-depressive-like forced swim tail suspension behavioral tests stressor-induced responses were blunted. Both neurochemical (norepinephrine, serotonin, dopamine) observed brains mice. review will discuss recent evidence involvement pathophysiology propose mechanisms by altered signaling through this ion may affect state brain.