Evaluation of a new simple collection device for sampling of microparticles in exhaled breath.
作者： Sabina Seferaj , Shahid Ullah , Åsa Tinglev , Sten Carlsson , Jesper Winberg
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摘要: The microparticle fraction of exhaled breath is interest for developing clinical biomarkers. Exhaled particles may contain non-volatile components from all parts the airway system, formed during normal breathing. This study aimed to evaluate a new, simple sampling device, based on impaction, collecting microparticles breath. Performance new device was compared with that existing SensAbues membrane filter device. analytical work used liquid chromatography-tandem mass spectrometry methods. collected three subsamples and these were separately analysed eight individuals. No difference observed between centre position (0.91 ng/sample) side positions (1.01 using major phosphatidylcholine (PC) 16:0/16:0 as analyte. patients methadone maintenance treatment. intra-individual variability in measured concentration collectors 8.7%. In another experiment treatment, efficiency an established Compared 121% greater 1450% DPPC. data lipid analysis also indicated larger material distal parts. Finally, optical particle counter preferentially collects fraction. conclusion, this demonstrates usefulness performance superior several aspects.
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