Hindbrain signals in otic regionalization: walk on the wild side.

摘要: The inner ear, the sensory organ responsible for hearing and balance, contains specialized non-sensory epithelia arranged in a highly complex three-dimensional structure. To achieve this level of complexity, tight coordination between morphogenesis cell fate specification is essential during otic development. Tissues surrounding primordium more particularly adjacent segmented hindbrain, have been implicated conferring signals required ear In review, we present current view on role hindbrain axial ear. functional analysis mutants segmentation genes, as well investigation signaling pathways potentially involved, all point to an FGF, Wnt Hh regionalization. However, these data provide conflicting evidence regarding involvement regionalization fish amniotes. We discuss possible origin differences.