Modeling Cost–Benefit Decision Making in Aged Rodents

摘要: Aging can impact choices between alternatives that differ with respect to relative benefits and “costs” (e.g., time delays or risk); however, much remains be learned about the specific cognitive, affective, neural factors govern choice behavior across life span. Relative primates, rodents offer both comparatively short spans facilitate longitudinal evaluation of cognition, enhanced tractability genetic, cellular, biochemical approaches important for identifying neurobiological mechanisms mediate decision making. This chapter will describe modeling cost–benefit making in aged rodents, a focus on intertemporal risky choice. In addition, examples provided how these have yielded convergent findings animal human subjects, as well novel data regarding neurobehavioral age-related alterations potential directions future research.