Structure and Function of the Steroid and Nuclear Receptor DNA Binding Domain

摘要: The nuclear receptors form the largest known superfamily of genes encoding eukaryotic transcription factors. To date, over 150 related have been identified, all which encode proteins with a common molecular architecture, shown in Figure 1 (reviewed by Mangelsdorf et al 1995). Most function as homo- or heterodimers, and bind selectively to gene-regulatory sequences called hormone response elements (HREs) through they regulate expression their target genes. These genes, turn, are responsible for controlling growth, development, metabolism homeostasis higher eukaryotes. Nuclear-receptor-mediated transcriptional control is dependent on paired assembly receptors, sequence, orientation, spacing half-site repeats HREs. recognition events focus this review. functions also involve ligand occupancy (for hormone/steroid receptors), complex interaction mediators basal machinery, will not be discussed here.