Development of Telintra as an Inhibitor of Glutathione S-Transferase P.
作者： Jie Zhang , Zhi-Wei Ye , Yvonne Janssen-Heininger , Danyelle M. Townsend , Kenneth D. Tew
DOI: 10.1007/164_2020_392
关键词:
摘要: Glutathione S-transferase P (GSTP) is a component of complex series pathways that provide cellular redox homeostasis. It an abundant protein in certain tumors and over-expressed cancer drug resistance. has diverse functions include, thiolase activities with small electrophilic agents or susceptible cysteine residues on the to mediate S-glutathionylation, chaperone binding select kinases. Preclinical clinical testing nanomolar inhibitor GSTP, TLK199 (Telintra; Ezatiostat) indicated role for enzyme hematopoiesis utility treatment patients myelodysplastic syndrome.
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