The fate of the filaria Monanema martini in two rodent hosts: recovery rate, migration, and localization.

摘要: In Meriones unguiculatus , the recovery rate of 80 inoculated larvae was low (about 20 %) and irregular. natural host Lemniscomys striatus about 50 % with doses 30, or 400 L3, but slightly higher for L3. This constant from day 2 to month 8 post infection (p. i.). When 7-9 reinoculations were performed in one year, late inoculation only 14 %.After subcutaneous inoculations, penetrated into peripheric lymphatic vessels hour 6 p. i. migrated lombar mesenteric lymphnodes ; this first migratory phase achieved 5 days Later, digestive tract system. Filarial localization did not depend upon L3 dose: half found caecum anterior colon (3 cm) wall, distributed posterior colon, mesentery small intestine. A number (3-5 filariae pulmonary blood vessels, as a result accidental migration by thoracic canal. similar phenomenon is known Brugia spp. rodents Conispiculum flavescens lizard. Several arguments suggest that genus Monanema fundamentally lymphatic.Migrations life system seems be more usual than it generally admitted. onchocerciasis, may at least partially explain lymphopathology inguinal region.