SUMO, PTEN, and tumor suppression
作者： Michael J. Matunis , Catherine M. Guzzo
DOI: 10.1111/PCMR.12001
关键词:
摘要: Phosphatase and tensin homologue deleted on chromosome 10 (PTEN) was identified in 1997 as a tumor suppressor gene through mapping of homozygous mutations occurring multiple sporadic types patients with cancer predisposition syndromes including Cowden disease (Song et al., 2012). Since that time, PTEN has emerged one the most frequently mutated or genes human cancers, skin cancers. In particular, loss function mutation deletion been observed up to 70% melanoma cell lines, epigenetic silencing 30-40% malignant melanomas (Mehnert Kluger,
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