Theory of protein secondary structure and algorithm of its prediction.
作者： O. B. Ptitsyn , A. V. Finkelstein
关键词:
摘要: A molecular theory of protein secondary structure is presented that takes account both local interactions inside each chain region and long-range between different regions, incorporating all these in a single Ising-like model. Local are evaluated from the stereochemical describing relative stabilities α- β-structures for residues synthetic polypeptides, while effects approximated by interaction with averaged hydrophobic template. Based on this theory, an algorithm prediction proposed examples given “blind” predictions made before x-ray structural data became available.
sci-hub.se 参考文章(31)
A.V. Finkelstein, O.B. Ptitsyn, A theory of protein molecule self-organization Journal of Molecular Biology. ,vol. 103, pp. 15- 24 ,(1976) , 10.1016/0022-2836(76)90049-8
Peter Y. Chou, Gerald D. Fasman, Conformational parameters for amino acids in helical, beta-sheet, and random coil regions calculated from proteins. Biochemistry. ,vol. 13, pp. 211- 222 ,(1974) , 10.1021/BI00699A001
Shigeo Kubota, Gerald D. Fasman, The β conformation of polypeptides of valine, isoleucine, and threonine in solution and solid-state: Optical and infrared studies† Biopolymers. ,vol. 14, pp. 605- 631 ,(1975) , 10.1002/BIP.1975.360140314
A. V. Finkelstein, O. B. Ptitsyn, S. A. Kozitsyn, Theory of protein molecule self-organization. II. A comparison of calculated thermodynamic parameters of local secondary structures with experiments Biopolymers. ,vol. 16, pp. 497- 524 ,(1977) , 10.1002/BIP.1977.360160303
T.N. Bhat, D.M. Blow, P. Brick, J. Nyborg, Tyrosyl-tRNA synthetase forms a mononucleotide-binding fold Journal of Molecular Biology. ,vol. 158, pp. 699- 709 ,(1982) , 10.1016/0022-2836(82)90255-8
R. A. Fredrickson, M. C. Chang, S. P. Powers, H. A. Scheraga, Helix-coil stability constants for the naturally occurring amino acids in water. 19. Isoleucine parameters from random poly[(hydroxypropyl)glutamine-co-L-isoleucine] Macromolecules. ,vol. 14, pp. 625- 632 ,(1981) , 10.1021/MA50004A034
Michael Levitt, Cyrus Chothia, Structural patterns in globular proteins Nature. ,vol. 261, pp. 552- 558 ,(1976) , 10.1038/261552A0
M. H. Hecht, B. O. Zweifel, H. A. Scheraga, Helix-Coil Stability Constants for the Naturally Occurring Amino Acids in Water. 17. Threonine Parameters from Random Poly(hydroxylbutylglutamine-co-L-threonine) Macromolecules. ,vol. 11, pp. 545- 551 ,(1978) , 10.1021/MA60063A024
CYRUS CHOTHIA, Hydrophobic bonding and accessible surface area in proteins. Nature. ,vol. 248, pp. 338- 339 ,(1974) , 10.1038/248338A0
O.B. Ptitsyn, Protein folding: general physical model FEBS Letters. ,vol. 131, pp. 197- 202 ,(1981) , 10.1016/0014-5793(81)80367-5