Virtual Screening for RNA-Interacting Small Molecules

摘要: Computational virtual screening is useful and powerful strategy for rapid discovery of small biologically active molecules in the early stage drug discovery. The a broad range important biological processes involved by RNA has increased importance as new target. To apply structure-based methods to RNA-binding ligands, many 3D structure prediction programs optimized docking algorithms have been developed. In this chapter, number successful cases targeting will be introduced.