Childhood onset schizophrenia: support for a progressive neurodevelopmental disorder.

摘要: Abstract Structural brain abnormalities have become an established feature of schizophrenia and increasing evidence points towards the progressive nature these abnormalities. The are most profound in early onset cases, which a severe, treatment refractory phenotype more salient genetic features. Unique insights could thus be gained pathology from studying earliest manifestations illness. This paper reviews updates findings on anatomic development patients with very while showing preliminary data ongoing studies. Collectively, our studies demonstrate that childhood-onset (COS) subjects show loss gray matter, delayed/disrupted white matter (WM) growth, decline cerebellar volume, some shared by their healthy siblings. developmental patterns or ‘trajectories’ often striking than differences at any one point time; highlighting importance longitudinal sibling partially (GM) deficits appear to normalize age, along other analyses, provide ‘patterns/trajectories’ for several regions particular ages useful endophenotypes (trait markers).