Macaques as model hosts for studies of HIV-1 infection.

摘要: Increasing evidence indicates that the host range of primate lentiviruses is in part determined by their ability to counteract innate restriction factors are effectors type 1 interferon (IFN-1) response. For HIV-1, vitro experiments have shown its tropism may be narrow and limited humans chimpanzees because replication other nonhuman species hindered such as TRIM5α, APOBEC3G, Tetherin. Based on these data, it has been hypothesized will infect replicate a new if they able evade suppression IFN-1 Several studies tested whether engineering HIV-1 recombinants with minimal amounts SIV sequences would enable CD4+ T-cells non-natural hosts Asian macaques proposed infection macaque could used study transmission pathogenesis. Indeed, viruses revealed Vif-mediated counteraction APOBEC3G function central cross-species but IFN-induced also play important roles controlling replication. Further models derivatives provide valuable insights into interaction immune response how adapt cause disease.