Comparative Veterinary Pharmacokinetics

摘要: In veterinary clinical practice the sensitivity of a given animal species to certain drug can be attributed pharmacodynamic and pharmacokinetic variations. contrast human medicine where individual differences are primary importance, interspecies also inter-breed distinctions crucial in comparative medicine. Pharmacokinetics describes behaviour body. Similarly nomenclature, ADME process absorption (other than IV adiministration), distribution, metabolism elimination drugs. To produce systemic effect, must absorbed distributed attain therapeutic concentration at site action. If target is GI tract, then no needed after oral application. Significant variations seen extent rate manner between species. Because pronounced extrapolation parameters from data or other origin inappropriate hazardous case several Lack however, necessitates empiric application extrapolated dosages many cases. This chapter concentrates on animals different species, breed age.