Regulation of riboflavin biosynthesis and transport genes in bacteria by transcriptional and translational attenuation

摘要: The riboflavin biosynthesis in bacteria was analyzed using comparative analysis of genes, operons and regulatory elements. A model for regulation based on formation alternative RNA structures involving the RFN elements is suggested. In Gram-positive including actinomycetes, Thermotoga, Thermus Deinococcus, metabolism transport genes are predicted to be regulated by transcriptional attenuation, whereas most Gram-negative bacteria, seem level translation initiation. Several new candidate transporters were identified (impX Desulfitobacterium halfniense Fusobacterium nucleatum; pnuX several some Corynebacterium species Strepto myces coelicolor; rfnT Rhizobiaceae). Traces a number likely horizontal transfer events found: complete operon with upstream element transferred Haemophilus influenzae Actinobacillus pleuropneumoniae from bacterium; non-regulated Pyrococcus furiousus Thermotoga; inserted into Pseudomonas aeruginosa other species, where it had ribH2 gene.