CD117, but not lysozyme, is positive in cutaneous plasmacytoma.
作者： Bruce R. Smoller , Ilene B. Bayer-Garner , Mary R. Schwartz , Pei Lin
DOI: 10.1043/1543-2165(2003)127<1596:CBNLIP>2.0.CO;2
关键词:
摘要: Abstract Context.—CD117 (c-Kit) and lysozyme are frequently expressed by myeloblasts sensitive markers for the diagnosis of extramedullary myeloid tumor. The cutaneous plasmacytoma presents a degree difficulty, particularly with plasmablastic variant, which can mimic hematologic as well epithelioid malignancies. Approximately 25% multiple myelomas express CD117 in bone marrow flow cytometry. Lysozyme immunoreactivity has been previously shown 30% poorly differentiated myelomas, while it is nonreactive nonmalignant plasma cells. Objective.—To ascertain whether aid plasmacytomas, type. Design.—Pathology reports 2357 patients myeloma were reviewed to find 13 plasmacytomas (8 Bartl grade II, 5 III). Formalin-fixed, paraffin-embedded tissue sections stained on Dako Autostainer system. Setting....
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K Boo, S Cheng, A morphological and immunohistochemical study of plasma cell proliferative lesions. The Malaysian journal of pathology. ,vol. 14, pp. 45- 48 ,(1992)
R. García-Sanz, J. Bladé, J. Almeida, M. J. Moro, M. Rozman, M. González, J. Hernández, J. F. San Miguel, C. López-Berges, D. Caballero, A. Orfao, L. Escribano, M. Ocqueteau, Immunophenotypic characterization of plasma cells from monoclonal gammopathy of undetermined significance patients. Implications for the differential diagnosis between MGUS and multiple myeloma. American Journal of Pathology. ,vol. 152, pp. 1655- 1665 ,(1998)
R. Bartl, B. Frisch, R. Burkhardt, A. Fateh- Moghadam, G. Mahl, P. Gierster, M. Sund, G. Kettner, Bone marrow histology in myeloma: its importance in diagnosis, prognosis, classification and staging British Journal of Haematology. ,vol. 51, pp. 361- 375 ,(1982) , 10.1111/J.1365-2141.1982.00361.X
B.Jack Longley, Maria Jose Reguera, Yongsheng Ma, Classes of c-KIT activating mutations: proposed mechanisms of action and implications for disease classification and therapy. Leukemia Research. ,vol. 25, pp. 571- 576 ,(2001) , 10.1016/S0145-2126(01)00028-5
Hisako Suwabe, Akihiko Serizawa, Hiroshi Kajiwara, Muneo Ohkido, Yutaka Tsutsumi, Degenerative processes of elastic fibers in sun-protected and sun-exposed skin : Immunoelectron microscopic observation of elastin, fibrillin-1, amyloid P component, lysozyme and α1-antitrypsin Pathology International. ,vol. 49, pp. 391- 402 ,(1999) , 10.1046/J.1440-1827.1999.00889.X
Marcia L. Lux, Brian P. Rubin, Tara L. Biase, Chang-Jie Chen, Timothy Maclure, George Demetri, Sheng Xiao, Samuel Singer, Christopher D.M. Fletcher, Jonathan A. Fletcher, KIT extracellular and kinase domain mutations in gastrointestinal stromal tumors. American Journal of Pathology. ,vol. 156, pp. 791- 795 ,(2000) , 10.1016/S0002-9440(10)64946-2
JohnR. Durant, WilliamE. Barry, Norman Learner, THE CHANGING FACE OF MYELOMA The Lancet. ,vol. 287, pp. 119- 121 ,(1966) , 10.1016/S0140-6736(66)91259-1
James W. Patterson, Jerome M. Parsons, Robert M. White, James E. Fitzpatrick, Elfriede Kohout-Dutz, Cutaneous involvement of multiple myeloma and extramedullary plasmacytoma Journal of the American Academy of Dermatology. ,vol. 19, pp. 879- 890 ,(1988) , 10.1016/S0190-9622(88)70249-2
S. Albrecht, L. From, H. J. Kahn, Lysozyme in abnormal dermal elastic fibers of cutaneous aging, solar elastosis and pseudoxanthoma elasticum Journal of Cutaneous Pathology. ,vol. 18, pp. 75- 80 ,(1991) , 10.1111/J.1600-0560.1991.TB00131.X
L. Al Safadi, U. Hellerich, H.E. Schaefer, The Expression of Lysozyme in Multiple Myeloma Pathology Research and Practice. ,vol. 190, pp. 578- 583 ,(1994) , 10.1016/S0344-0338(11)80395-X