Diagnostic potential of mannose binding lectin (MBL) gene polymorphism in rheumatoid arthritis patients

摘要: Abstract Background Rheumatoid arthritis (RA) is a chronic joint inflammatory condition which can result in damage to the cartilage and bone. RA susceptibility pathophysiology have been associated with activation of innate immune pathway. The mannose binding lectin (MBL) activates complement system key component immunity. Aim work To study diagnostic potential MBL2 genetic variants flowing serum MBL levels their probable function as marker for relation disease activity. Patients methods included 60 patient 15 age sex matched control. Detection level gene type polymorphism by polymerized chain reactin (PCR). visual analogue-scale (VAS) activity score (DAS28) were assessed. Results patients; 51 females 9 males (F:M 5.7:1) mean 42.2 ± 8.03 years (36–51) duration 5 ± 2.8 (3–7 years). patients was significantly higher (92.7 ± 78 ng/dl) than control (83.8 ± 62.9 ng/dl) (p  Conclusion There strong correlation between alleles (B D) protein Egyptian populations.