The methylenation of enolizable ketones and esters using organotitanium chemistry
作者： Leigh Clawson , Stephen L. Buchwald , Robert H. Grubbs
DOI: 10.1016/S0040-4039(01)81672-5
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摘要: Abstract The titanium methylidene fragment, Cp 2 TiCH , resulting from Tebbe's reagent, TiCH ·AlMe Cl or the β,β-disubstituted metallacycle, CP C(Me)(n-Pr)CH methylenates enolizable acidic ketones and converts α,α-disubstituted into enolates. reagent reacts selectively with over esters.
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