Mediators and Some Cytokines in Tears During the Late Conjunctival Response Induced by Primary Allergic Reaction in the Nasal Mucosa

摘要: The allergic conjunctivitis (AC) consists of five clinical types, a seasonal (SAC), perennial (PAC), vernal keratoconjunctivitis (VKC), atopic (AKC) and giant papillary (GPC), having common causal background, namely the involvement component, but different features. 1-5 types AC can occur in 2 basic forms, primary secondary form, with respect to locality initial antigen-antibody/sensitized Th1 cells interaction following steps, called reaction. 6-12 In reaction all subsequent due direct exposure conjunctivae by an external allergen, is localized conjunctival tissue. these, classical, tissue site together target affected directly displaying characteristic symptoms. taking place nasal mucosa, induces subsequently form through various possible mechanisms pathways. this case, factors released generated mucosa response symptoms may be considered as consequence nose. both forms well hypersensitivity mechanisms, such immediate type (IgE-mediated Type I), late (Type III) or delayed (cellmediated IV), involved.1, 2, 5, 9-19 results then development (CR) allergen (challenge), (ICR), (LCR), dual (DLCR, being combination type), (DYCR) (DDYCR, type). 13, 5-14, 20 demonstrated provocation tests allergens (CPTs), whereas secondarily induced only confirmed (NPTs) registration signs subjective