Membranes, molecules and biophysics: enhancing monocyte derived dendritic cell (MDDC) immunogenicity for improved anti-cancer therapy

摘要: Despite great medical advancement in the treatment of cancer, cancer remains a disease global significance. Chemotherapeutics can be very expensive and drain resources at national level some cases cost is so that it prohibits their use by local health authorities. Drug resistance also major limiting factor to successful with many patients initially responding well but then becoming refractory same drug case may become multi-drug resistant. The immune system known important prevention tumors eliminating pre-cancerous or cancerous cells. This concept surveillance has largely been super-ceded immunoediting whereby imposes selective pressure on tumor cells which either control growth inadvertently select for have evolved escape response induce development. Stimulation vaccination offers benefits cancer. It highly effective vaccines manipulated include multi-antigens overcome equilibrium (and pressure) while preventing establishment reactivated cells, since antigen-specific memory would induced following initial vaccination/booster phase. To date studies using as little disappointing, probably due insufficient immunogenicity. In this review we will discuss methods manipulation increase anti-cancer activity dendritic vivo how monocyte derived ex provide more robust, patient-specific treatments.