Increasing rates of malarial fever with deteriorating immune status in HIV-1-infected Ugandan adults.

摘要: Background: Falciparum malaria and HIV-1 infection are two of the most important health problems facing sub-Saharan Africa. No convincing evidence an association between symptomatic has been found. Objective: To investigate effect HIV-associated immunosuppression on malarial fever rates. Design: An observational cohort study in HIV-specific, primary healthcare clinics Entebbe, Uganda, 1371 HIV-1-infected adults participating a randomized trial 23-valent pneumococcal vaccine. Methods: Cohort members underwent routine 6 monthly surveillance had open clinic access when sick. Episodes were assessed according to standardized protocols. Rates described HIV immune status determined by CD4 T cell counts. Results: Incidence rates Plasmodium falciparum showed marked inverse relationship with count; 140, 93 57 cases per 1000 pyo for groups 500 respectively, P< 0.001. Malarial definitions incorporating parasite density criteria (derived from asymptomatic surveillance) correct chance findings P. parasitaemia, did not affect incidence immunosuppression. Conclusion: These data support interaction HIV. Emphasis mosquito avoidance measures should be component education counselling HIV/AIDS patients malaria-endemic areas, suggests additional HIV-related public problem (C) 2001 Lippincott Williams & Wilkins.