the extent to which immunity, apoptosis and detoxification gene expression interact with 17 alpha-methyltestosterone

摘要: Innate immunity is the first line of defence against invasion by foreign pathogens. One widely used synthetic androgen for production all-male fish, particularly commercially valuable Nile tilapia, Oreochromis niloticus, 17 alpha-methyltestosterone (MT). The present study investigates effect MT on innate immunity, cellular apoptosis and detoxification mortality rate, during after feeding fry with 0-, 40-and 60-mg MT/kg. Expression analysis was completed interleukin 1 beta (il1β), 8 (il8), tumour necrosis factor alpha (tnfα), CXC2- CC-chemokines, interferon (ifn), myxovirus resistance (mx), toll-like receptor 7 (tlr7), immunoglobulin M heavy chain (IgM chain), vitellogenin (vtg), susceptibility (cas) glutathione S-transferase α1 (gstα1). revealed that had a significant impact these genes, this varied from induction to repression treatment. Linear regression showed association between majority tested gene transcript levels rates 7th 21st days hormonal treatment 2 weeks following cessation. results are thoroughly discussed in article. This report concerning hazardous series genes involved tilapia fry.