Exposure to traffic-related particle matter and effects on lung function and potential interactions in a cross-sectional analysis of a cohort study in west Sweden.

摘要: Objectives To investigate the long-term effects of source-specific particle matter (PM) on lung function, Surfactant Protein A (SP-A) and glutathione S-transferase (GST) genes GSTP1 GSTT1 gene variants effect modification by single-nucleotide polymorphism (SNP) genotype. Design Cohort study with address-based annual PM exposure assigned from estimates size (PM10, PM2.5 PMBC) (traffic, industry, marine traffic wood burning) dispersion modelling. Setting Gothenburg, Sweden. Participants The ADult-Onset asthma NItric oXide Study had 6685 participants recruited general population, which 5216 (78%) were included in current information all variables interest. Mean age at time enrolment was 51.4 years (range 24–76) 2427 (46.5%) men. Primary secondary outcome measures primary forced vital capacity (FVC) expiratory volume 1 s (FEV1). Secondary gene–environment interactions SP-A genotypes. Results Exposure to traffic-related PM10 associated decreases percent-predicted (% predicted) FEV1 −0.48% (95% CI −0.89% −0.07%) −0.47% −0.88% per IQR 3.05 2.47 µg/m3, respectively, % predicted FVC −0.46% −0.83% −0.08%) −0.10%). Total PMBC strongly both −0.53 −0.94 −0.13%) −0.43% −0.77 −0.09%) IQR, for FVC, similarly FEV1. Minor allele carrier status two SNPs null genotype function. Three showed industry traffic. Conclusions exposure, specifically related, reductions not modified Genetic suggested PM2.5.