Fibroblast growth factor 21 and its novel association with oxidative stress.
作者： Miguel Ángel Gómez-Sámano , Mariana Grajales-Gómez , Julia María Zuarth-Vázquez , Ma. Fernanda Navarro-Flores , Mayela Martínez-Saavedra
DOI: 10.1016/J.REDOX.2016.12.024
关键词:
摘要: Fibroblast growth factor 21 (FGF21) is an endocrine-member of the FGF family. It synthesized mainly in liver, but it also expressed adipose tissue, skeletal muscle, and many other organs. has a key role glucose lipid metabolism, as well energy balance. FGF21 concentration plasma increased patients with obesity, insulin resistance, metabolic syndrome. Recent findings suggest that such increment protects tissue from oxidative stress environment. Different types physical stress, strenuous exercising, lactation, diabetic nephropathy, cardiovascular disease, critical illnesses, increase circulating concentration. now considered stress-responsive hormone humans. The discovery essential response element gene, for activating transcription 4 (ATF4), involved regulation its relation genes NRF2, TBP-2, UCP3, SOD2, ERK, p38, places regulator cell response. Its chronic diseases involvement treatment follow-up these been recently target new studies. diminished through pathways observed anti-diabetic therapy another clue insights this hormone.
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