Histone acetyltransferase activators and uses thereof
作者： Ottavio Arancio , Donald W. Landry , Yitshak Francis , Mauro Fa , Yan Feng
DOI:
关键词:
摘要: The invention provides for a method screening compounds that bind to and modulate histone acetyltransferase protein. further methods treating neurodegenerative disorders, conditions associated with accumulated amyloid-beta peptide deposits, Tau protein levels, and/or accumulations of alpha-synuclein as well cancer by administering HAT-activating compound subject.
lens.org 参考文章(277)
Q. Wang, Beta-amyloid-mediated inhibition of NMDA receptor-dependent long-term potentiation induction involves activation of microglia and stimulation of inducible nitric oxide synthase and superoxide. The Journal of Neuroscience. ,vol. 24, pp. 6049- 6056 ,(2004) , 10.1523/JNEUROSCI.0233-04.2004
E. R. Kandel, The Molecular Biology of Memory Storage: A Dialogue Between Genes and Synapses Science. ,vol. 294, pp. 1030- 1038 ,(2001) , 10.1126/SCIENCE.1067020
Indrani Rajan, Katerina V. Savelieva, Gui-Lan Ye, Ching-yun Wang, Murtaza M. Malbari, Carl Friddle, Thomas H. Lanthorn, Wandong Zhang, Loss of the Putative Catalytic Domain of HDAC4 Leads to Reduced Thermal Nociception and Seizures while Allowing Normal Bone Development PLoS ONE. ,vol. 4, pp. e6612- ,(2009) , 10.1371/JOURNAL.PONE.0006612
Glenn H. Kawasaki, Cell-free synthesis and isolation of novel genes and polypeptides ,(1990)
W. Blaine Stine, Karie N. Dahlgren, Grant A. Krafft, Mary Jo LaDu, In Vitro Characterization of Conditions for Amyloid-β Peptide Oligomerization and Fibrillogenesis Journal of Biological Chemistry. ,vol. 278, pp. 11612- 11622 ,(2003) , 10.1074/JBC.M210207200
K. Mantelingu, A. Hari Kishore, K. Balasubramanyam, G. V. Pavan Kumar, M. Altaf, S Nanjunda Swamy, Ruthrotha Selvi, Chandrima Das, Chandrabhas Narayana, K. S. Rangappa, Tapas K. Kundu, Activation of p300 histone acetyltransferase by small molecules altering enzyme structure: probed by surface-enhanced raman spectroscopy Journal of Physical Chemistry B. ,vol. 111, pp. 4527- 4534 ,(2007) , 10.1021/JP067655S
Alon Monsonego, Jaime Imitola, Victor Zota, Takatoku Oida, Howard L. Weiner, Microglia-Mediated Nitric Oxide Cytotoxicity of T Cells Following Amyloid β-Peptide Presentation to Th1 Cells Journal of Immunology. ,vol. 171, pp. 2216- 2224 ,(2003) , 10.4049/JIMMUNOL.171.5.2216
Benjamin A. Auspitz, Michael A. Foley, Margaret S. Lee, Grant R. Zimmermann, Curtis Keith, M. James Nichols, Methods for the treatment of neoplasms ,(2003)
Roussoudan Bourtchuladze, Bruno Frenguelli, Julie Blendy, Diana Cioffi, Gunther Schutz, Alcino J. Silva, Deficient long-term memory in mice with a targeted mutation of the cAMP-responsive element-binding protein Cell. ,vol. 79, pp. 59- 68 ,(1994) , 10.1016/0092-8674(94)90400-6
R. J. Simon, R. S. Kania, R. N. Zuckermann, V. D. Huebner, D. A. Jewell, S. Banville, S. Ng, L. Wang, S. Rosenberg, C. K. Marlowe, Peptoids: a modular approach to drug discovery. Proceedings of the National Academy of Sciences of the United States of America. ,vol. 89, pp. 9367- 9371 ,(1992) , 10.1073/PNAS.89.20.9367