Recurrence patterns identify aggressive form of human papillomavirus-dependent vulvar cancer.

摘要: Background: Vulvar cancer is rare and, as a result, understudied. Treatment is predominantly surgery, irrespective of the type vulvar cancer, and associated with physical, emotional sexual complications. A cluster human papillomavirus (HPV)-dependent patients was identified in Arnhem Land Northern Territory (NT), Australia, which young Indigenous women were diagnosed at 70 times national incidence rate. Aims: To assess whether from Arnhem Land differ women with squamous cell carcinoma (VSCC) intraepithelial neoplasia (VIN) resident elsewhere NT recurrence after treatment, disease progression mortality. Materials methods: retrospective cohort study NT-resident women diagnosed with VIN or invasive between 1 January 1993 and 30 June 2015 undertaken. Time to assessed using cumulative incidence plots Fine Gray competing risk regression models. Mean cumulative count used estimate burden recurrent events. Results: experienced more recurrences after treatment than non-Indigenous women, cancers recurred faster, and Indigenous have worse survival five years. Conclusions: In characterising epidemiological features this cluster, we have particularly aggressive form cancer. This provides a unique opportunity for elucidating aetiopathological pathways driving vulvar cancer development that may ultimately lead preventive therapeutic targets for neglected malignancy. Further, these findings important implications for clinical practice HPV vaccination policy affected population.