Cyclic AMP as the second hormonal messenger in the in vitro folliculogenesis of the foetal thyroid gland of the rat.

作者: Pierre Pic , Lionel Remy , Evelyne Mazzella , Suzanne Rua

DOI: 10.1007/BF00222374

关键词:

摘要: Thyroid-stimulating hormone, the catecholamine isoproterenol, and prostaglandins E1 E2, all substances known to increase cAMP concentration in thyroid tissue, accelerate formation of follicular cavities explanted 15-day-old rat foetuses. Dibutyryl-cAMP added medium, but not sodium fluoride, also stimulates folliculogenesis. Since fluoride membrane adenylate cyclase does intracellular level, these results show that is involved as a second messenger activation foetal morphogenesis induced by hormones. They indicate gland capable responding hormonal stimulation early 15th day pregnancy; this implies on 15, possesses receptors only for thyroid-stimulating catecholamines prostaglandins.

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