FE3+/2+-NO DONOR MIXED-VALENCE COORDINATION POLYMER AND APPLICATION THEREOF
作者： Huang Zhangjian , Lyu Tian , Hu Yihui , Ding Ya
DOI:
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摘要: The invention discloses an Fe -NO donor mixed-valence coordination polymer 4(BPDB)(H2O)2. In the molecular formula 4(BPDB)(H2O)2, represents and , BPDB a NO donor: 1,5-(L-proline azoarsen-O -)-2,4-dinitrobenzene. further provides nano-particle of polymer. has relatively high water solubility stability is capable passively targeting tumors through permeability retention effect (EPR effect) solid tumor; releasing producing ROS under response high-concentration GSH H2O2 in tumor microenvironment, so that efficient, low-toxicity synergistic treatment realized.
lens.org 参考文章(5)
Daniela Andrei, Anna E. Maciag, Harinath Chakrapani, Michael L. Citro, Larry K. Keefer, Joseph E. Saavedra, Aryl bis(diazeniumdiolates): potent inducers of S-glutathionylation of cellular proteins and their in vitro antiproliferative activities. Journal of Medicinal Chemistry. ,vol. 51, pp. 7944- 7952 ,(2008) , 10.1021/JM800831Y
Enika Nagababu, Ferriheme catalyzes nitric oxide reaction with glutathione to form S-nitrosoglutathione: A novel mechanism for formation of S-nitrosothiols Free Radical Biology and Medicine. ,vol. 101, pp. 296- 304 ,(2016) , 10.1016/J.FREERADBIOMED.2016.09.015
Thai Thanh Hoang Thi, Yunki Lee, Phuong Le Thi, Ki Dong Park, Nitric oxide-releasing injectable hydrogels with high antibacterial activity through in situ formation of peroxynitrite. Acta Biomaterialia. ,vol. 67, pp. 66- 78 ,(2017) , 10.1016/J.ACTBIO.2017.12.005
Liu Aiyun, Zhang Ning, Zhang Can, Zhang Wenjie, Ding Ya, Method for preparing shrapnel type anti-tumor gold nano conjugate heterozygous liposome and application thereof ,(2015)
Li Dahong, Han Tong, Zhao Nan, Tian Kangtao, Hu Xu, Hua Huiming, Li Zhanlin, Fang Chunyan, Furazan NO donor type evodiamine derivatives with anti-tumor activity ,(2016)