摘要: Cycoloxygenase-2 (COX-2) induction is prevalent in a variety of (brain and peripheral) injury models where COX-2 levels correlate with disease progression. Thus, has been widely explored for anti-inflammatory therapy inhibitors, which proved to be effective reducing the pain inflammation patients arthritis menstrual cramps, but they have not provided any benefit chronic inflammatory neurodegenerative disease. Recently, two drugs, rofecoxib valdecoxib, were withdrawn from United States market due cardiovascular side effects. future could targeted through specific prostanoid receptor downstream COX-2. The PGE2 EP2 emerging as pro-inflammatory target CNS peripheral diseases. Here we highlight latest developments on role diseases, mechanism activation, small molecule discovery either enhance or block function this receptor.
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