Mast Cells and Asthma

摘要: Publisher Summary Mast cells are primary effector of immediate hypersensitivity reactions, and constitutively found in gas exchange conducting regions the human lung. Proteases, along with histamine heparin proteoglycan, major constituents mast cell secretory granules, serve to divide into two phenotypes. MCTC contain tryptase, chymase, carboxypeptidase neutrophil cathepsin G, whereas MCT tryptase alone. account for nearly all present alveolar wall, while an increasing portion as one moves up airway. In nasal mucosa, approximately equal proportions these types found. Throughout airway, predominant type epithelium, often reside near mucous glands airway smooth muscle. active atopics asthma or rhinitis, increased numbers appear epithelium. This may bronchoalveolar lavage fluid, induced sputum bronchial brushings from asthmatics, also, part, increase clinical sensitivity inhaled aeroallergens. However, total lung do not be increased. Instead, is characterized by ongoing activation