Triglyceride glucose-waist circumference, a novel and effective predictor of diabetes in first-degree relatives of type 2 diabetes patients: cross-sectional and prospective cohort study

摘要: Body mass index (BMI), waist circumference (WC), visceral adiposity (VAI), triglyceride glucose (TyG), TyG-BMI, and TyG-WC have been reported as markers of insulin resistance or type 2 diabetes mellitus (T2DM). However, little is known about the associations between aforementioned risk prediabetes in first-degree relatives (FDRs) T2DM patients. 1544 FDRs patients (635 men 909 women) were enrolled initial cross-sectional study all them finished corresponding examinations. Logistic regression analysis receiver operating characteristic (ROC) curve used to compare identify six parameters (BMI, WC, VAI, TyG, TyG-BMI TyG-WC) with prevalence diabetes. Subsequently, 452 followed-up for an average 5 years. Cox proportional hazard model was applied confirm predictive value optimal marker. Among indices, more strongly associated Compared participants lowest quartile TyG-WC, adjusted odds ratio 95 % CIs 11.19 (7.62–16.42) those top TyG-WC. Moreover, largest AUC also observed (0.765, 0.741–0.789, P < 0.001). The robust further confirmed follow-up (HR: 7.13, 3.41–14.90, a novel clinically effective marker early identifying risks