The Role of miRNAs in the Development of Normal Pancreas and Pancreatic Cancer, and Their Roles in Tumor Progression
作者： Yiwei Li , Dejuan Kong , Aamir Ahmad , Bin Bao , Fazlul H. Sarkar
DOI: 10.1007/978-1-4899-8065-6_10
关键词:
摘要: The microRNAs (miRNAs) have been shown to play important roles in the control of many normal biological processes including cell differentiation and organogenesis. During development pancreas, several miRNAs miR-375, miR-7, miR-124, etc. regulate exocrine endocrine differentiation. These regulations could part be mediated through miRNA-mediated deregulation transforming growth factor-β, Notch, Hedgehog signaling, which are signal transduction pathways that critically involved organogenesis during development. However, deregulated expression also lead progression pancreatic cancer. Moreover, known maintenance cancer stem cells epithelial-to-mesenchymal transition phenotypic cells, typically responsible for drug resistance, tumor recurrence, metastasis. Therefore, targeting specific by oligonucleotide/nanoparticle vector delivery or regulation natural agents become novel strategies treatment with better outcome combination conventional therapeutics.
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