Factors associated with lung function impairment in children and adults with obstructive lung disease

摘要: Obstructive lung diseases are a group of in which there is limitation the flow air into or out lungs. Two common such asthma, found both children and adults, chronic obstructive pulmonary disease (COPD), mainly population over 50 years age. Both asthma COPD seem to have with several different subgroups, phenotypes, may be associated long term consequences regard morbidity some cases also mortality. To able prevent treat these best possible way, we need learn more about phenotypes mechanisms behind them. The aim this thesis was study factors that function impairment adults diseases. focus age onset, duration symptoms, sex, allergy, smoking contribution genes environment. We have, two first papers, measured at 4 8 birth cohort 4,000 symptom onset life was, on level, impaired exhaled flows. This irrespective persistence symptoms between 8. could show tracking flows Sensitization airway allergens only after 4. While male sex risk factor for girls showed larger negative effect flows, least four years. In paper 3 4, studied data from 45,000 twins Swedish Twin Registry quantify heritability bronchitis emphysema, main components seen COPD. As behaviour has genetic influences, it necessary how smoking. results ~40% individuals liability developing bronchitis/emphysema can attributed factors, small part were those influencing habits. Women often reported bronchitis/emphysema, compared men, not explained by habits genes. hundred took clinical testing measures. all measures had heritable component, women than men. conclusion, disease. summary, importance future function. Children outgrow their seem, loose rather impairment, might present through life. furthermore shown important individuals’ adult Sex differences exist disease, indications less favourable outcome girls/women. More work now needed find belong susceptible groups, develop apply methods LIST OF PUBLICATIONS based following referred text Roman numerals (I-IV). I. Hallberg J, Anderson M, Wickman Svartengren M. influences medication childhood asthma. Acta Paediatr 2006:95;11911196. II. Development among (BAMSE). Submitted. III. Dominicus A, Eriksson UK, Gerhardsson de Verdier Pedersen NL, Dahlback Nihlen U, Higenbottam T, Interaction development bronchitis. Am J Respir Crit Care Med 2008;177(5):486-90. IV. Iliadou without respiratory symptoms.