Dihydroxyphenylalanine in Extrapyramidal Disease

摘要: EVIDENCE has been accumulating for the past several years which implicated dopamine metabolism in production of extrapyramidal symptoms. Drugs such as reserpine tend to produce symptoms a side effect have shown deplete from brain. It is also considerable interest that found highest concentration basal ganglia 1 while 1-norepinephrine and serotonin, other important amines central nervous system, are present relatively smaller concentrations this area More recently Ehringer Hornykiewicz 2 demonstrated brains obtained parkinsonian patients who died result sudden trauma contained very low levels dopamine. All these findings suggest possibility disturbance synthesis or degradation might be involved etiology disturbances. For we conducting studies