Topical Delivery of Withania somnifera Crude Extracts in Niosomes and Solid Lipid Nanoparticles.

摘要: Background Withania somnifera is a medicinal plant native to India and known have anticancer properties. It has been investigated for its anti-melanoma properties, since melanoma presents on the skin, it prudent probe use of W. in topical formulations. To enhance drug delivery allow controlled release, niosomes solid lipid nanoparticles (SLNs) as vesicles were explored. Objective The objective this study determine stability crude extracts encapsulated SLNs. Materials Methods Water, ethanol, 50% ethanol prepared using 24 h soxhlet extraction which each Franz cell diffusion studies conducted with release skin penetration phytomolecules, withaferin A, withanolide A. Results niosome SLN formulations had average sizes ranging from 165.9 ± 9.4 304.6 52.4 nm extract having largest size. A small particle size seemed correlated low encapsulation efficiency (EE) but high EE There was significant difference (P < 0.05) between amount that released formulations, only managed deliver stratum corneum-epidermis epidermis-dermis layers skin. Conclusion SLNs able encapsulate marker compounds, certain SUMMARY water, solvents. These three then incorporated into studies, thus resulting six (ethanol niosome, water SLN, SLN). two compounds (withaferin A) determined. Abbreviations used: API: Active pharmaceutical ingredient, ANOVA: Analysis variance, ED: Epidermis-dermis, HPLC: High-performance liquid chromatography, HLB: Hydrophilic-lipophilic balance, NMR: Nuclear magnetic resonance spectroscopy, PDI: Polydispersity index, SLN: Solid nanoparticle, SD: Standard deviation, SCE: Stratum corneum-epidermis, TEM: Transmission electron microscopy.