Hormonal Regulation of Casein Gene Expression in Normal and Neoplastic Cells in Murine Mammary Glands

摘要: Contemporary advances of knowledge and technology in the areas cellular molecular biology have revealed that selective gene expression plays a definitive role regulation differentiation. In conventional terms, denotes regulated transcription different structural genes producing respective mRNAs. During recent years it has also become evident physical structure eukaryotic are composed expressed (exons) unexpressed (introns) segments along DNA strand this requires splicing processing initial transcripts into final mRNA (20), (50), (119). Moreover, post-translational polypeptides may modify product hence influence (108). Thus, during developmental process be subject to modulation at any these complex series events. Based on observation insect steroid hormone, ecdysone, is capable inducing specific puffs polytene chromosomes Drosophila larvae, Karlson (55) proposed hormonal processes target tissue. Demonstration ecdysone-induced synthesis enzyme, dopa decarboxylase larvae (101), correlation between puff formation (31), cell-free translation for (56) now appear corroborate Karlson’s original thesis.